Alleviation of exhaustion-induced immunosuppression and sepsis by immune checkpoint blockers sequentially administered with antibiotics—analysis of a new mathematical model

BACKGROUND: Sepsis-associated immune dysregulation, involving hyper-inflammation and immunosuppression, is common in intensive care patients, often leading to multiple organ dysfunction and death. The aim of this study was to identify the main driving force underlying immunosuppression in sepsis, an...

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Sparad:
Bibliografiska uppgifter
I publikationen:Intensive Care Med Exp
Huvudupphovsmän: Gillis, Avi, Beil, Michael, Halevi-Tobias, Karin, van Heerden, Peter Vernon, Sviri, Sigal, Agur, Zvia
Materialtyp: Artigo
Språk:Inglês
Publicerad: Springer International Publishing 2019
Ämnen:
Research
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6560115/
https://ncbi.nlm.nih.gov/pubmed/31187301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40635-019-0260-3
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