Alleviation of exhaustion-induced immunosuppression and sepsis by immune checkpoint blockers sequentially administered with antibiotics—analysis of a new mathematical model

BACKGROUND: Sepsis-associated immune dysregulation, involving hyper-inflammation and immunosuppression, is common in intensive care patients, often leading to multiple organ dysfunction and death. The aim of this study was to identify the main driving force underlying immunosuppression in sepsis, an...

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Detalhes bibliográficos
Publicado no:Intensive Care Med Exp
Main Authors: Gillis, Avi, Beil, Michael, Halevi-Tobias, Karin, van Heerden, Peter Vernon, Sviri, Sigal, Agur, Zvia
Formato: Artigo
Idioma:Inglês
Publicado em: Springer International Publishing 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6560115/
https://ncbi.nlm.nih.gov/pubmed/31187301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40635-019-0260-3
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