Kalirin-7 prevents dendritic spine dysgenesis induced by amyloid beta-derived oligomers

Synapse degeneration and dendritic spine dysgenesis are believed to be crucial early steps in Alzheimer’s disease (AD), and correlate with cognitive deficits in AD patients. Soluble amyloid beta (Aβ)-derived oligomers, also termed Aβ-derived diffusible ligands (ADDLs), accumulate in the brain of AD...

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Bibliographic Details
Published in:Eur J Neurosci
Main Authors: Xie, Zhong, Shapiro, Lauren P., Cahill, Michael E., Russell, Theron A., Lacor, Pascale N., Klein, William L., Penzes, Peter
Format: Artigo
Language:Inglês
Published: 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6559832/
https://ncbi.nlm.nih.gov/pubmed/30565792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/ejn.14311
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