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NMR Reveals that GU Base Pairs Flanking Internal Loops can Adopt Diverse Structures

RNA thermodynamics play an important role in determining the 2D and 3D structures of RNA. Internal loops of the sequence, 5’-GMNU/3’-UNMG, are relatively unstable thermodynamically. Here, five GU flanked 2×2 nucleotide internal loops were structurally investigated in order to reveal determinants for...

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Detalhes bibliográficos
Publicado no:Biochemistry
Main Authors: Berger, Kyle D., Kennedy, Scott D., Turner, Douglas H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6559796/
https://ncbi.nlm.nih.gov/pubmed/30702283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.8b01027
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