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NMR Reveals that GU Base Pairs Flanking Internal Loops can Adopt Diverse Structures

RNA thermodynamics play an important role in determining the 2D and 3D structures of RNA. Internal loops of the sequence, 5’-GMNU/3’-UNMG, are relatively unstable thermodynamically. Here, five GU flanked 2×2 nucleotide internal loops were structurally investigated in order to reveal determinants for...

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Publicado en:Biochemistry
Autores principales: Berger, Kyle D., Kennedy, Scott D., Turner, Douglas H.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2019
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6559796/
https://ncbi.nlm.nih.gov/pubmed/30702283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.8b01027
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