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High titer rheumatoid arthritis antibodies preferentially bind fibrinogen citrullinated by peptidyl arginine deiminase 4.
OBJECTIVE. Most patients with rheumatoid arthritis (RA) harbor antibodies to citrullinated autoantigens, such as citrullinated fibrinogen. Two isoforms of peptidyl arginine deiminase (PAD), PAD2 and PAD4, which catalyze citrullination with different substrate specificities, can be detected in RA syn...
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| Pubblicato in: | Arthritis Rheumatol |
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| Autori principali: | , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6559740/ https://ncbi.nlm.nih.gov/pubmed/28029744 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.40035 |
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