Examining the effects of the histone methyltransferase inhibitor BIX-01294 on histone modifications and gene expression in both a clinical population and mouse models

Schizophrenia has been consistently characterized by abnormal patterns of gene down-regulation, increased restrictive chromatin assemblies, and reduced transcriptional activity. Histone methyltransferase (HMT) mRNA and H3K9me2 levels are elevated in postmortem brain and peripheral blood cells of per...

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Foilsithe in:PLoS One
Main Authors: Chase, Kayla A., Feiner, Benjamin, Ramaker, Marcia J., Hu, Edward, Rosen, Cherise, Sharma, Rajiv P.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Public Library of Science 2019
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6559633/
https://ncbi.nlm.nih.gov/pubmed/31185023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0216463
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