Silencing of the FTO gene inhibits insulin secretion: An in vitro study using GRINCH cells

Expression of fat mass and obesity-associated gene (FTO) and ADP-ribosylation factor-like 15 (ARL15) in human islets is inversely correlated with HbA(1c). However, their impact on insulin secretion is still ambiguous. Here in, we investigated the role of FTO and ARL15 using GRINCH (Glucose-Responsiv...

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Detalhes bibliográficos
Publicado no:Mol Cell Endocrinol
Main Authors: Taneera, Jalal, Prasad, Rashmi B., Dhaiban, Sarah, Mohammed, Abdul Khader, Haataja, Leena, Arvan, Peter, Hamad, Mawieh, Groop, Leif, Wollheim, Claes B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6559235/
https://ncbi.nlm.nih.gov/pubmed/29890211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mce.2018.06.003
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