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ABCA1 is Necessary for Bexarotene-Mediated Clearance of Soluble Amyloid Beta from the Hippocampus of APP/PS1 Mice

Alzheimer’s disease (AD) is characterized by impaired clearance of amyloid beta (Aβ) peptides, leading to the accumulation of Aβ in the brain and subsequent neurodegeneration and cognitive impairment. ApoE plays a critical role in the proteolytic degradation of soluble forms of Aβ. This effect is de...

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Dades bibliogràfiques
Publicat a:J Neuroimmune Pharmacol
Autors principals: Corona, Angela W., Kodoma, Nathan, Casali, Brad T., Landreth, Gary E.
Format: Artigo
Idioma:Inglês
Publicat: 2015
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6558963/
https://ncbi.nlm.nih.gov/pubmed/26175148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11481-015-9627-8
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