Harmine suppresses hyper-activated Ras–MAPK pathway by selectively targeting oncogenic mutated Ras/Raf in Caenorhabditis elegans

BACKGROUND: Mutationally activated Ras proteins are closely linked to a wide variety of human cancers. Hence, there has been an intensive search for anti-Ras therapies for cancer treatment. The sole Ras gene, which encodes LET-60, in Caenorhabditis elegans regulates vulval development. While the los...

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Veröffentlicht in:Cancer Cell Int
Hauptverfasser: Ji, Jiaojiao, Yuan, Jiang, Guo, Xiaoyu, Ji, Ruifang, Quan, Qinghua, Ding, Mei, Li, Xia, Liu, Yonggang
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2019
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Primary Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6558680/
https://ncbi.nlm.nih.gov/pubmed/31198408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12935-019-0880-4
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