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Synthesis of Substituted Benzaldehydes via a Two-Step, One-Pot Reduction/Cross-Coupling Procedure

[Image: see text] The synthesis of functionalized (benz)aldehydes, via a two-step, one-pot procedure, is presented. The method employs a stable aluminum hemiaminal as a tetrahedral intermediate, protecting a latent aldehyde, making it suitable for subsequent cross-coupling with (strong nucleophilic)...

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Detalhes bibliográficos
Publicado no:Org Lett
Main Authors: Heijnen, Dorus, Helbert, Hugo, Luurtsema, Gert, Elsinga, Philip H., Feringa, Ben L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2019
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6558639/
https://ncbi.nlm.nih.gov/pubmed/31083960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.orglett.9b01274
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