Functionality and Cell Senescence of CD4/ CD8-Selected CD20 CAR T Cells Manufactured Using the Automated CliniMACS Prodigy® Platform

Clinical studies using autologous CAR T cells have achieved spectacular remissions in refractory CD19+ B cell leukaemia, however some of the patient treatments with CAR T cells failed. Beside the heterogeneity of leukaemia, the distribution and senescence of the autologous cells from heavily pretrea...

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Detalhes bibliográficos
Publicado no:Transfus Med Hemother
Main Authors: Aleksandrova, Krasimira, Leise, Jana, Priesner, Christoph, Melk, Anette, Kubaink, Fanni, Abken, Hinrich, Hombach, Andreas, Aktas, Murat, Essl, Mike, Bürger, Iris, Kaiser, Andrew, Rauser, Georg, Jurk, Marion, Goudeva, Lilia, Glienke, Wolfgang, Arseniev, Lubomir, Esser, Ruth, Köhl, Ulrike
Formato: Artigo
Idioma:Inglês
Publicado em: S. Karger AG 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6558326/
https://ncbi.nlm.nih.gov/pubmed/31244581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000495772
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