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Eltrombopag: a powerful chelator of cellular or extracellular iron(III) alone or combined with a second chelator

Eltrombopag (ELT) is a thrombopoietin receptor agonist reported to decrease labile iron in leukemia cells. Here we examine the previously undescribed iron(III)-coordinating and cellular iron-mobilizing properties of ELT. We find a high binding constant for iron(III) (log β(2)=35). Clinically achieva...

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Bibliografske podrobnosti
izdano v:	Blood
Main Authors:	Vlachodimitropoulou, Evangelia, Chen, Yu-Lin, Garbowski, Maciej, Koonyosying, Pimpisid, Psaila, Bethan, Sola-Visner, Martha, Cooper, Nichola, Hider, Robert, Porter, John
Format:	Artigo
Jezik:	Inglês
Izdano:	2017
Teme:	Article
Online dostop:	https://ncbi.nlm.nih.gov/pmc/articles/PMC6558288/ https://ncbi.nlm.nih.gov/pubmed/28864815 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2016-10-740241
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Eltrombopag: a powerful chelator of cellular or extracellular iron(III) alone or combined with a second chelator

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