Eltrombopag: a powerful chelator of cellular or extracellular iron(III) alone or combined with a second chelator

Eltrombopag (ELT) is a thrombopoietin receptor agonist reported to decrease labile iron in leukemia cells. Here we examine the previously undescribed iron(III)-coordinating and cellular iron-mobilizing properties of ELT. We find a high binding constant for iron(III) (log β(2)=35). Clinically achieva...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Blood
Main Authors: Vlachodimitropoulou, Evangelia, Chen, Yu-Lin, Garbowski, Maciej, Koonyosying, Pimpisid, Psaila, Bethan, Sola-Visner, Martha, Cooper, Nichola, Hider, Robert, Porter, John
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6558288/
https://ncbi.nlm.nih.gov/pubmed/28864815
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2016-10-740241
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados