Alemtuzumab in Multiple Sclerosis: Short- and Long-Term Effects of Immunodepletion on the Peripheral Treg Compartment

Treatment with alemtuzumab is followed by an early increase in Treg frequencies. Whether naïve and memory subsets are differentially affected and how depletion influences dysfunctional MS-Treg is unclear. In this study, we analyzed the effect of alemtuzumab on regulatory T-cells (Treg) in patients w...

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Detalles Bibliográficos
Publicado en:Front Immunol
Main Authors: Haas, Jürgen, Würthwein, Cornelia, Korporal-Kuhnke, Mirjam, Viehoever, Andrea, Jarius, Sven, Ruck, Tobias, Pfeuffer, Steffen, Meuth, Sven G., Wildemann, Brigitte
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2019
Assuntos:
Immunology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6558003/
https://ncbi.nlm.nih.gov/pubmed/31214176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.01204
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