Alemtuzumab in Multiple Sclerosis: Short- and Long-Term Effects of Immunodepletion on the Peripheral Treg Compartment

Treatment with alemtuzumab is followed by an early increase in Treg frequencies. Whether naïve and memory subsets are differentially affected and how depletion influences dysfunctional MS-Treg is unclear. In this study, we analyzed the effect of alemtuzumab on regulatory T-cells (Treg) in patients w...

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Dettagli Bibliografici
Pubblicato in:Front Immunol
Autori principali: Haas, Jürgen, Würthwein, Cornelia, Korporal-Kuhnke, Mirjam, Viehoever, Andrea, Jarius, Sven, Ruck, Tobias, Pfeuffer, Steffen, Meuth, Sven G., Wildemann, Brigitte
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2019
Soggetti:
Immunology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6558003/
https://ncbi.nlm.nih.gov/pubmed/31214176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.01204
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