Glycolysis upregulation is neuroprotective as a compensatory mechanism in ALS

Amyotrophic Lateral Sclerosis (ALS), is a fatal neurodegenerative disorder, with TDP-43 inclusions as a major pathological hallmark. Using a Drosophila model of TDP-43 proteinopathy we found significant alterations in glucose metabolism including increased pyruvate, suggesting that modulating glycol...

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Publicado en:eLife
Autores principales: Manzo, Ernesto, Lorenzini, Ileana, Barrameda, Dianne, O'Conner, Abigail G, Barrows, Jordan M, Starr, Alexander, Kovalik, Tina, Rabichow, Benjamin E, Lehmkuhl, Erik M, Shreiner, Dakotah D, Joardar, Archi, Liévens, Jean-Charles, Bowser, Robert, Sattler, Rita, Zarnescu, Daniela C
Formato: Artigo
Lenguaje:Inglês
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Neuroscience
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6557627/
https://ncbi.nlm.nih.gov/pubmed/31180318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.45114
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