The rs17084733 variant in the KIT 3’ UTR disrupts a miR-221/222 binding site in gastrointestinal stromal tumour: a sponge-like mechanism conferring disease susceptibility

Several miRNAs are dysregulated in gastrointestinal stromal tumours (GIST), and miR-221/222 appear to have a prominent role in GIST biology. Therefore, we investigated the role of DNA variants located in miR-221/222 precursor sequences and their target KIT 3'UTR. Ninety-five polymorphisms were...

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Detalhes bibliográficos
Publicado no:Epigenetics
Main Authors: Ravegnini, Gloria, Serrano, César, Simeon, Vittorio, Sammarini, Giulia, Nannini, Margherita, Roversi, Erica, Urbini, Milena, Ferrè, Fabrizio, Ricci, Riccardo, Tarantino, Giuseppe, Pantaleo, Maria A., Hrelia, Patrizia, Angelini, Sabrina
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2019
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6557610/
https://ncbi.nlm.nih.gov/pubmed/30983504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15592294.2019.1595997
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