Personalized Medicine in Gastrointestinal Stromal Tumor (GIST): Clinical Implications of the Somatic and Germline DNA Analysis

Gastrointestinal stromal tumors (GIST) are the most common mesenchymal tumors of the gastrointestinal tract. They are characterized by gain of function mutations in KIT or PDGFRA tyrosine kinase receptors, with their consequent constitutive activation. The gold standard therapy is imatinib that offe...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Ravegnini, Gloria, Nannini, Margherita, Sammarini, Giulia, Astolfi, Annalisa, Biasco, Guido, Pantaleo, Maria A., Hrelia, Patrizia, Angelini, Sabrina
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2015
Assuntos:
Review
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4519915/
https://ncbi.nlm.nih.gov/pubmed/26184165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms160715592
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