Dual Src and MEK inhibition decreases ovarian cancer growth and targets tumor initiating stem-like cells

PURPOSE: Rational targeted therapies are needed for treatment of ovarian cancers. Signaling kinases, Src and MAPK, are activated in high grade serous ovarian cancer (HGSOC). Here, we tested the frequency of activation of both kinases in HGSOC and the therapeutic potential of dual kinase inhibition....

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Vydáno v:Clin Cancer Res
Hlavní autoři: Simpkins, Fiona, Jang, Kibeom, Yoon, Hyunho, Hew, Karina E., Kim, Minsoon, Azzam, Diana J., Sun, Jun, Zhao, Dekuang, Ince, Tan A., Liu, Wenbin, Guo, Wei, Wei, Zhi, Zhang, Gao, Mills, Gordon B., Slingerland, Joyce M.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6557165/
https://ncbi.nlm.nih.gov/pubmed/29959144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-17-3697
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