CCNE1 Amplification and Centrosome Number Abnormality in Serous Tubal Intraepithelial Carcinoma- Further Evidence Supporting its Role as a Precursor of Ovarian High-Grade Serous Carcinoma

Aberration in chromosomal structure characterizes almost all cancers and has profound biological significance in tumor development. It can be facilitated by various mechanisms including overexpression of cyclin E1 and centrosome amplification. Since ovarian high-grade serous carcinoma has pronounced...

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Veröffentlicht in:Mod Pathol
Hauptverfasser: Kuhn, Elisabetta, Wang, Tian-Li, Doberstein, Kai, Bahadirli-Talbott, Asli, Ayhan, Ayse, Sehdev, Ann Smith, Drapkin, Ronny, Kurman, Robert J., Shih, Ie-Ming
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6557162/
https://ncbi.nlm.nih.gov/pubmed/27443516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/modpathol.2016.101
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