TP53 mutations in serous tubal intraepithelial carcinoma and concurrent pelvic high-grade serous carcinoma—evidence supporting the clonal relationship of the two lesions

Serous tubal intraepithelial carcinomas (STICs) have been proposed to be the most likely precursor of ovarian, tubal and ‘primary peritoneal’ (pelvic) high-grade serous carcinoma (HGSC). As somatic mutation of TP53 is the most common molecular genetic change of ovarian HGSC, occurring in more than 9...

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Detalhes bibliográficos
Publicado no:J Pathol
Main Authors: Kuhn, Elisabetta, Kurman, Robert J, Vang, Russell, Sehdev, Ann Smith, Han, Guangming, Soslow, Robert, Wang, Tian-Li, Shih, Ie-Ming
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4782784/
https://ncbi.nlm.nih.gov/pubmed/21990067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/path.3023
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