Defining the earliest step of cardiovascular lineage segregation by single cell RNA-seq

Mouse heart development arises from Mesp1 expressing cardiovascular progenitors (CPs) that are specified during gastrulation. The molecular processes that control early regional and lineage segregation of CPs remain unclear. Here, we performed single cell RNA-sequencing of WT and Mesp1 null CPs. We...

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Vydáno v:Science
Hlavní autoři: Lescroart, Fabienne, Wang, Xiaonan, Lin, Xionghui, Swedlund, Benjamin, Gargouri, Souhir, Sànchez-Dànes, Adriana, Moignard, Victoria, Dubois, Christine, Paulissen, Catherine, Kinston, Sarah, Göttgens, Berthold, Blanpain, Cédric
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6556615/
https://ncbi.nlm.nih.gov/pubmed/29371425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aao4174
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