Chemical suppression of specific C-C chemokine signaling pathways enhances cardiac reprogramming

Reprogramming of fibroblasts into induced cardiomyocytes (iCMs) is a potentially promising strategy for regenerating a damaged heart. However, low fibroblast–cardiomyocyte conversion rates remain a major challenge in this reprogramming. To this end, here we conducted a chemical screen and identified...

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Udgivet i:J Biol Chem
Main Authors: Guo, Yijing, Lei, Ienglam, Tian, Shuo, Gao, Wenbin, Hacer, Karatas, Li, Yangbing, Wang, Shaomeng, Liu, Liu, Wang, Zhong
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2019
Fag:
Cell Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6556576/
https://ncbi.nlm.nih.gov/pubmed/31023824
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.006000
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