CD45RA(+)CCR7(−) CD8 T cells lacking co-stimulatory receptors demonstrate enhanced frequency in peripheral blood of NSCLC patients responding to nivolumab

BACKGROUND: Checkpoint inhibitors have become standard care of treatment for non-small cell lung cancer (NSCLC), yet only a limited fraction of patients experiences durable clinical benefit, highlighting the need for markers to stratify patient populations. METHODS: To prospectively identify patient...

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Detalhes bibliográficos
Publicado no:J Immunother Cancer
Main Authors: Kunert, Andre, Basak, Edwin A., Hurkmans, Daan P., Balcioglu, Hayri E., Klaver, Yarne, van Brakel, Mandy, Oostvogels, Astrid A. M., Lamers, Cor H. J., Bins, Sander, Koolen, Stijn L. W., van der Veldt, Astrid A. M., Sleijfer, Stefan, Mathijssen, Ron H. J., Aerts, Joachim G. J. V., Debets, Reno
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6555948/
https://ncbi.nlm.nih.gov/pubmed/31176366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40425-019-0608-y
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