Androgen receptor antagonism accelerates disease onset in the SOD1(G93A) mouse model of amyotrophic lateral sclerosis

BACKGROUND AND PURPOSE: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease typically more common in males, implicating androgens in progression of both patients and mouse models. Androgen effects are mediated by androgen receptor which is highly expressed in spinal motor neuron...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: McLeod, Victoria M., Lau, Chew L., Chiam, Mathew D.F., Rupasinghe, Thusitha W., Roessner, Ute, Djouma, Elvan, Boon, Wah C., Turner, Bradley J.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6555856/
https://ncbi.nlm.nih.gov/pubmed/30849180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14657
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