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Androgen receptor antagonism accelerates disease onset in the SOD1(G93A) mouse model of amyotrophic lateral sclerosis
BACKGROUND AND PURPOSE: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease typically more common in males, implicating androgens in progression of both patients and mouse models. Androgen effects are mediated by androgen receptor which is highly expressed in spinal motor neuron...
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Publicado no: | Br J Pharmacol |
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Main Authors: | , , , , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
John Wiley and Sons Inc.
2019
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6555856/ https://ncbi.nlm.nih.gov/pubmed/30849180 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14657 |
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