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Targeting of the AXL receptor tyrosine kinase by small molecule inhibitor leads to AXL cell surface accumulation by impairing the ubiquitin-dependent receptor degradation
BACKGROUND: Overexpression of AXL receptor tyrosine kinase (AXL) in various human cancers correlates with reduced patients overall survival and resistance to first line therapies. Therefore, several AXL tyrosine kinase inhibitors (TKIs) are currently under clinical evaluation. RESULTS: AXL TKI BMS77...
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| 發表在: | Cell Commun Signal |
|---|---|
| Main Authors: | , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
BioMed Central
2019
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6555758/ https://ncbi.nlm.nih.gov/pubmed/31171001 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12964-019-0377-8 |
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