Inhibiting receptor tyrosine kinase AXL with small molecule inhibitor BMS-777607 reduces glioblastoma growth, migration, and invasion in vitro and in vivo

PURPOSE: Receptor tyrosine kinase AXL (RTK-AXL) is regarded as suitable target in glioma therapy. Here we evaluate the anti-tumoral effect of small molecule inhibitor BMS-777607 targeting RTK-AXL in a preclinical glioma model and provide evidence that RTK-AXL is expressed and phosphorylated in prima...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Onken, Julia, Torka, Robert, Korsing, Sören, Radke, Josefine, Krementeskaia, Irina, Nieminen, Melina, Bai, Xi, Ullrich, Axel, Heppner, Frank, Vajkoczy, Peter
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4891090/
https://ncbi.nlm.nih.gov/pubmed/26848524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.7130
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