DDR2 controls breast tumor stiffness and metastasis by regulating integrin mediated mechanotransduction in CAFs

Biomechanical changes in the tumor microenvironment influence tumor progression and metastases. Collagen content and fiber organization within the tumor stroma are major contributors to biomechanical changes (e., tumor stiffness) and correlated with tumor aggressiveness and outcome. What signals and...

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Udgivet i:eLife
Main Authors: Bayer, Samantha VH, Grither, Whitney R, Brenot, Audrey, Hwang, Priscilla Y, Barcus, Craig E, Ernst, Melanie, Pence, Patrick, Walter, Christopher, Pathak, Amit, Longmore, Gregory D
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications, Ltd 2019
Fag:
Cancer Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6555593/
https://ncbi.nlm.nih.gov/pubmed/31144616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.45508
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