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Inhibition of tumor–microenvironment interaction and tumor invasion by small-molecule allosteric inhibitor of DDR2 extracellular domain

The action of the collagen binding receptor tyrosine kinase (RTK) discoidin domain receptor 2 (DDR2) in both tumor and tumor stromal cells has been established as critical for breast cancer metastasis. Small molecule inhibitors that target the extracellular domain of RTKs are rare, as they have clas...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Grither, Whitney R., Longmore, Gregory D.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6099886/
https://ncbi.nlm.nih.gov/pubmed/30061414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1805020115
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