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Inhibition of tumor–microenvironment interaction and tumor invasion by small-molecule allosteric inhibitor of DDR2 extracellular domain

The action of the collagen binding receptor tyrosine kinase (RTK) discoidin domain receptor 2 (DDR2) in both tumor and tumor stromal cells has been established as critical for breast cancer metastasis. Small molecule inhibitors that target the extracellular domain of RTKs are rare, as they have clas...

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Publié dans:Proc Natl Acad Sci U S A
Auteurs principaux: Grither, Whitney R., Longmore, Gregory D.
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2018
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6099886/
https://ncbi.nlm.nih.gov/pubmed/30061414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1805020115
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