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Inhibition of tumor–microenvironment interaction and tumor invasion by small-molecule allosteric inhibitor of DDR2 extracellular domain

The action of the collagen binding receptor tyrosine kinase (RTK) discoidin domain receptor 2 (DDR2) in both tumor and tumor stromal cells has been established as critical for breast cancer metastasis. Small molecule inhibitors that target the extracellular domain of RTKs are rare, as they have clas...

Täydet tiedot

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Bibliografiset tiedot
Julkaisussa:Proc Natl Acad Sci U S A
Päätekijät: Grither, Whitney R., Longmore, Gregory D.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: National Academy of Sciences 2018
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6099886/
https://ncbi.nlm.nih.gov/pubmed/30061414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1805020115
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