A new heparan sulfate from the mollusk Nodipecten nodosus inhibits merozoite invasion and disrupts rosetting and cytoadherence of Plasmodium falciparum

BACKGROUND: Despite treatment with effective antimalarial drugs, the mortality rate is still high in severe cases of the disease, highlighting the need to find adjunct therapies that can inhibit the adhesion of Plasmodium falciparum-infected erythrocytes (Pf-iEs). OBJECTIVES: In this context, we eva...

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Библиографические подробности
Опубликовано в: :Mem Inst Oswaldo Cruz
Главные авторы: Bastos, Marcele F, Albrecht, Letusa, Gomes, Angélica M, Lopes, Stefanie CP, Vicente, Cristina P, de Almeida, Rodrigo PM, Cassiano, Gustavo C, Fonseca, Roberto JC, Werneck, Claudio C, Pavão, Mauro SG, Costa, Fabio TM
Формат: Artigo
Язык:Inglês
Опубликовано: Instituto Oswaldo Cruz, Ministério da Saúde 2019
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Original Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6555591/
https://ncbi.nlm.nih.gov/pubmed/31188952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1590/0074-02760190088
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