A new heparan sulfate from the mollusk Nodipecten nodosus inhibits merozoite invasion and disrupts rosetting and cytoadherence of Plasmodium falciparum

BACKGROUND: Despite treatment with effective antimalarial drugs, the mortality rate is still high in severe cases of the disease, highlighting the need to find adjunct therapies that can inhibit the adhesion of Plasmodium falciparum-infected erythrocytes (Pf-iEs). OBJECTIVES: In this context, we eva...

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Foilsithe in:Mem Inst Oswaldo Cruz
Main Authors: Bastos, Marcele F, Albrecht, Letusa, Gomes, Angélica M, Lopes, Stefanie CP, Vicente, Cristina P, de Almeida, Rodrigo PM, Cassiano, Gustavo C, Fonseca, Roberto JC, Werneck, Claudio C, Pavão, Mauro SG, Costa, Fabio TM
Formáid: Artigo
Teanga:Inglês
Foilsithe: Instituto Oswaldo Cruz, Ministério da Saúde 2019
Ábhair:
Original Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6555591/
https://ncbi.nlm.nih.gov/pubmed/31188952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1590/0074-02760190088
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