Upregulation of sphingosine-1-phosphate receptor 3 on fibroblast-like synoviocytes is associated with the development of collagen-induced arthritis via increased interleukin-6 production

BACKGROUND: Sphingosine-1-phosphate receptor 3 (S1P(3)) is one of five receptors for sphingosine-1-phosphate (S1P). S1P/S1P(3) signaling is involved in numerous physiological and pathological processes including bone metabolism, sepsis, cancer, and immunity. In rheumatoid arthritis (RA), fibroblast-...

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Pubblicato in:PLoS One
Autori principali: Inoue, Takuya, Kohno, Masataka, Nagahara, Hidetake, Murakami, Ken, Sagawa, Tomoya, Kasahara, Akiko, Kaneshita, Shunya, Kida, Takashi, Fujioka, Kazuki, Wada, Makoto, Nakada, Hiroshi, Hla, Timothy, Kawahito, Yutaka
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2019
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6555509/
https://ncbi.nlm.nih.gov/pubmed/31173610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0218090
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