Chronic lymphocytic leukemia derived interleukin-10 suppresses anti-tumor immunity

Chronic lymphocytic leukemia (CLL) patients progressively develop an immunosuppressive state. CLL patients have more plasma inerleukin-10 (IL-10), an anti-inflammatory cytokine, than healthy controls. In vitro human CLL cells produce IL-10 in response to B-cell receptor (BCR) cross-linking. We used...

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I publikationen:J Immunol
Huvudupphovsmän: Alhakeem, Sara S., McKenna, Mary K., Oben, Karine Z., Noothi, Sunil K., Rivas, Jacqueline R., Hildebrandt, Gerhard C., Fleischman, Roger A., Rangnekar, Vivek M., Muthusamy, Natarajan, Bondada, Subbarao
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2018
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6555426/
https://ncbi.nlm.nih.gov/pubmed/29712773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1800241
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