ATXN2-AS, a Gene Antisense to ATXN2, Is Associated with Spinocerebellar Ataxia Type 2 and Amyotrophic Lateral Sclerosis

OBJECTIVE: Spinocerebellar ataxia type 2 (SCA2) is a neurodegenerative disease caused by a CAG repeat expansion in the gene ataxin-2 (ATXN2). ATXN2 intermediate-length CAG expansions were identified as a risk factor for amyotrophic lateral sclerosis (ALS). The ATXN2 CAG repeat is translated into pol...

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Publicado no:Ann Neurol
Main Authors: Li, Pan P., Sun, Xin, Xia, Guangbin, Arbez, Nicolas, Paul, Sharan, Zhu, Shanshan, Peng, H. Benjamin, Ross, Christopher A., Koeppen, Arnulf H., Margolis, Russell L., Pulst, Stefan M., Ashizawa, Tetsuo, Rudnicki, Dobrila D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6555153/
https://ncbi.nlm.nih.gov/pubmed/27531668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ana.24761
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