Inhibition of GSK-3 to induce cardiomyocyte proliferation: a recipe for in situ cardiac regeneration

With an estimated 38 million current patients, heart failure (HF) is a leading cause of morbidity and mortality worldwide. Although the aetiology differs, HF is largely a disease of cardiomyocyte (CM) death or dysfunction. Due to the famously limited amount of regenerative capacity of the myocardium...

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Veröffentlicht in:Cardiovasc Res
Hauptverfasser: Singh, Anand Prakash, Umbarkar, Prachi, Guo, Yuanjun, Force, Thomas, Gupte, Manisha, Lal, Hind
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2019
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6555088/
https://ncbi.nlm.nih.gov/pubmed/30321309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvy255
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