OR04-3 Lysine-Specific Demethylase-1 (LSD1) Deficiency Increases Aldosterone Signaling via Mineralocorticoid Receptor Activation

Lysine-specific demethylase-1 (LSD1) is a histone demethylase that mediates epigenetic regulation of gene transcription. We have shown that human risk allele carriers of a LSD1 variant as well as a LSD1 heterozygous knockout mice (LSD1(+/-)) have salt sensitive hypertension (HTN), but low aldosteron...

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Bibliografische gegevens
Gepubliceerd in:J Endocr Soc
Hoofdauteurs: Treesaranuwattana, Thitinan, Williams, Gordon, Pojoga, Luminita
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Endocrine Society 2019
Onderwerpen:
Cardiovascular Endocrinology
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6555081/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/js.2019-OR04-3
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