OR04-3 Lysine-Specific Demethylase-1 (LSD1) Deficiency Increases Aldosterone Signaling via Mineralocorticoid Receptor Activation

Lysine-specific demethylase-1 (LSD1) is a histone demethylase that mediates epigenetic regulation of gene transcription. We have shown that human risk allele carriers of a LSD1 variant as well as a LSD1 heterozygous knockout mice (LSD1(+/-)) have salt sensitive hypertension (HTN), but low aldosteron...

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Bibliographic Details
Published in:J Endocr Soc
Main Authors: Treesaranuwattana, Thitinan, Williams, Gordon, Pojoga, Luminita
Format: Artigo
Language:Inglês
Published: Endocrine Society 2019
Subjects:
Cardiovascular Endocrinology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6555081/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/js.2019-OR04-3
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