Tumor-secreted PAI-1 promotes breast cancer metastasis via the induction of adipocyte-derived collagen remodeling

BACKGROUND: Breast cancer cells recruit surrounding stromal cells, such as cancer-associated fibroblasts (CAFs), to remodel collagen and promote tumor metastasis. Adipocytes are the most abundant stromal partners in breast tissue, local invasion of breast cancer leads to the proximity of cancer cell...

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Veröffentlicht in:Cell Commun Signal
Hauptverfasser: Wei, Xiaohui, Li, Sijing, He, Jinyong, Du, Hongzhi, Liu, Yang, Yu, Wei, Hu, Haolin, Han, Lifei, Wang, Chenfei, Li, Hongyang, Shi, Xin, Zhan, Meixiao, Lu, Ligong, Yuan, Shengtao, Sun, Li
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2019
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6554964/
https://ncbi.nlm.nih.gov/pubmed/31170987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12964-019-0373-z
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