Tumor-secreted PAI-1 promotes breast cancer metastasis via the induction of adipocyte-derived collagen remodeling

BACKGROUND: Breast cancer cells recruit surrounding stromal cells, such as cancer-associated fibroblasts (CAFs), to remodel collagen and promote tumor metastasis. Adipocytes are the most abundant stromal partners in breast tissue, local invasion of breast cancer leads to the proximity of cancer cell...

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Detalhes bibliográficos
Publicado no:Cell Commun Signal
Main Authors: Wei, Xiaohui, Li, Sijing, He, Jinyong, Du, Hongzhi, Liu, Yang, Yu, Wei, Hu, Haolin, Han, Lifei, Wang, Chenfei, Li, Hongyang, Shi, Xin, Zhan, Meixiao, Lu, Ligong, Yuan, Shengtao, Sun, Li
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6554964/
https://ncbi.nlm.nih.gov/pubmed/31170987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12964-019-0373-z
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