OR30-3 Structural Basis of Activation and Sustained Signaling by the PTH Receptor

Parathyroid hormone (PTH) receptor (PTHR) is a medically important family B G Protein Coupled Receptor (GPCR) that primarily couples to Gs/cAMP and Gq/Ca(2+) signaling pathways and has a central role in regulating Ca(2+) homeostasis and bone turnover. PTHR is activated by two endogenous hormones, en...

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Vydáno v:J Endocr Soc
Hlavní autoři: Sutkeviciute, Ieva, Zhao, Li-Hua, Zhang, Yan, Xu, H Eric, Vilardaga, Jean-Pierre
Médium: Artigo
Jazyk:Inglês
Vydáno: Endocrine Society 2019
Témata:
Bone and Mineral Metabolism
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6554852/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/js.2019-OR30-3
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