Stereochemical and Mechanistic Investigation of the Reaction Catalyzed by Fom3 from Streptomyces fradiae, a Cobalamin-Dependent Radical S-Adenosylmethionine Methylase

Fom3, a cobalamin-dependent radical S-adenosylmethionine (SAM) methylase, has recently been shown to catalyze the methylation of carbon 2” of cytidylyl-2-hydroxyethylphosphonate (HEP-CMP) to form cytidylyl-2-hydroxypropylphosphonate (HPP-CMP) during the biosynthesis of fosfomycin, a broad-spectrum a...

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Detalhes bibliográficos
Publicado no:Biochemistry
Main Authors: Wang, Bo, Blaszczyk, Anthony, Knox, Hayley L., Zhou, Shengbin, Blaesi, Elizabeth J., Krebs, Carsten, Wang, Roy X., Booker, Squire J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6554712/
https://ncbi.nlm.nih.gov/pubmed/30036047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.8b00693
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