T Cell-Specific Overexpression of Acid Sphingomyelinase Results in Elevated T Cell Activation and Reduced Parasitemia During Plasmodium yoelii Infection

The enzyme acid sphingomyelinase (ASM) hydrolyzes sphingomyelin to ceramide and is thereby involved in several cellular processes such as differentiation, proliferation, and apoptosis in different cell types. However, the function of ASM in T cells is still not well characterized. Here, we used T ce...

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Veröffentlicht in:Front Immunol
Hauptverfasser: Hose, Matthias, Günther, Anne, Abberger, Hanna, Begum, Salina, Korencak, Marek, Becker, Katrin A., Buer, Jan, Westendorf, Astrid M., Hansen, Wiebke
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2019
Schlagworte:
Immunology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6554418/
https://ncbi.nlm.nih.gov/pubmed/31214184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.01225
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