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T Cell-Specific Overexpression of Acid Sphingomyelinase Results in Elevated T Cell Activation and Reduced Parasitemia During Plasmodium yoelii Infection

The enzyme acid sphingomyelinase (ASM) hydrolyzes sphingomyelin to ceramide and is thereby involved in several cellular processes such as differentiation, proliferation, and apoptosis in different cell types. However, the function of ASM in T cells is still not well characterized. Here, we used T ce...

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Publicat a:Front Immunol
Autors principals: Hose, Matthias, Günther, Anne, Abberger, Hanna, Begum, Salina, Korencak, Marek, Becker, Katrin A., Buer, Jan, Westendorf, Astrid M., Hansen, Wiebke
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2019
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6554418/
https://ncbi.nlm.nih.gov/pubmed/31214184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.01225
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