T Cell-Specific Overexpression of Acid Sphingomyelinase Results in Elevated T Cell Activation and Reduced Parasitemia During Plasmodium yoelii Infection

The enzyme acid sphingomyelinase (ASM) hydrolyzes sphingomyelin to ceramide and is thereby involved in several cellular processes such as differentiation, proliferation, and apoptosis in different cell types. However, the function of ASM in T cells is still not well characterized. Here, we used T ce...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Hose, Matthias, Günther, Anne, Abberger, Hanna, Begum, Salina, Korencak, Marek, Becker, Katrin A., Buer, Jan, Westendorf, Astrid M., Hansen, Wiebke
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6554418/
https://ncbi.nlm.nih.gov/pubmed/31214184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.01225
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