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Diabetes causes marked inhibition of mitochondrial metabolism in pancreatic β-cells

Diabetes is a global health problem caused primarily by the inability of pancreatic β-cells to secrete adequate levels of insulin. The molecular mechanisms underlying the progressive failure of β-cells to respond to glucose in type-2 diabetes remain unresolved. Using a combination of transcriptomics...

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Библиографические подробности
Опубликовано в: :Nat Commun
Главные авторы: Haythorne, Elizabeth, Rohm, Maria, van de Bunt, Martijn, Brereton, Melissa F., Tarasov, Andrei I., Blacker, Thomas S., Sachse, Gregor, Silva dos Santos, Mariana, Terron Exposito, Raul, Davis, Simon, Baba, Otto, Fischer, Roman, Duchen, Michael R., Rorsman, Patrik, MacRae, James I., Ashcroft, Frances M.
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group UK 2019
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6554411/
https://ncbi.nlm.nih.gov/pubmed/31171772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-10189-x
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