Insulin-like growth factor-1 attenuates oxidative stress-induced hepatocyte premature senescence in liver fibrogenesis via regulating nuclear p53–progerin interaction

Stress-induced premature senescence (SIPS), a state of cell growth arrest due to various stimuli, is implicated in the pathogeneses of hepatic fibrogenesis. Progerin, a permanently farnesylated mutant lamin A protein, likely leads to premature senescence to influent liver diseases. The previous repo...

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Publicado en:Cell Death Dis
Autores principales: Luo, Xiaoying, Jiang, Xiaoke, Li, Jun, Bai, Yangqiu, Li, Zhen, Wei, Peiru, Sun, Suofeng, Liang, Yuan, Han, Shuangyin, Li, Xiuling, Zhang, Bingyong
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2019
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6554350/
https://ncbi.nlm.nih.gov/pubmed/31171766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-019-1670-6
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