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Sirtuin 1 ameliorates defenestration in hepatic sinusoidal endothelial cells during liver fibrosis via inhibiting stress‐induced premature senescence

OBJECTIVE: Premature senescence is related to progerin and involves in endothelial dysfunction and liver diseases. Activating sirtuin 1 (SIRT1) ameliorates liver fibrosis. However, the mechanisms of premature senescence in defenestration of hepatic sinusoidal endothelial cells (HSECs) and how SIRT1...

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Detalhes bibliográficos
Publicado no:Cell Prolif
Main Authors: Luo, Xiaoying, Bai, Yangqiu, He, Shuli, Sun, Suofeng, Jiang, Xiaoke, Yang, Zhiyu, Lu, Di, Wei, Peiru, Liang, Yuan, Peng, Cong, Wang, Yaru, Sheng, Ruli, Han, Shuangyin, Li, Xiuling, Zhang, Bingyong
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7941223/
https://ncbi.nlm.nih.gov/pubmed/33522656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cpr.12991
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