Defective Zn(2+) homeostasis in mouse and human platelets with α- and δ-storage pool diseases

Zinc (Zn(2+)) can modulate platelet and coagulation activation pathways, including fibrin formation. Here, we studied the (patho)physiological consequences of abnormal platelet Zn(2+) storage and release. To visualize Zn(2+) storage in human and mouse platelets, the Zn(2+) specific fluorescent dye F...

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Publicado no:Sci Rep
Main Authors: Kiran Gotru, Sanjeev, van Geffen, Johanna P., Nagy, Magdolna, Mammadova-Bach, Elmina, Eilenberger, Julia, Volz, Julia, Manukjan, Georgi, Schulze, Harald, Wagner, Leonard, Eber, Stefan, Schambeck, Christian, Deppermann, Carsten, Brouns, Sanne, Nurden, Paquita, Greinacher, Andreas, Sachs, Ulrich, Nieswandt, Bernhard, Hermanns, Heike M., Heemskerk, Johan W. M., Braun, Attila
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6554314/
https://ncbi.nlm.nih.gov/pubmed/31171812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-44751-w
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