Ndufs2, A Core Subunit of Mitochondrial Complex I, Is Essential for Acute Oxygen-Sensing and Hypoxic Pulmonary Vasoconstriction

RATIONALE: Hypoxic pulmonary vasoconstriction (HPV) optimizes systemic oxygen delivery by matching ventilation to perfusion. HPV is intrinsic to pulmonary artery smooth muscle cells (PASMC). Hypoxia dilates systemic arteries, including renal arteries. Hypoxia is sensed by changes in mitochondrial-de...

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Enregistré dans:
Détails bibliographiques
Publié dans:Circ Res
Auteurs principaux: Dunham-Snary, Kimberly J, Wu, Danchen, Potus, François, Sykes, Edward A, Mewburn, Jeffrey D, Charles, Rebecca L, Eaton, Philip, Sultanian, Richard A, Archer, Stephen L
Format: Artigo
Langue:Inglês
Publié: 2019
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6554062/
https://ncbi.nlm.nih.gov/pubmed/30922174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.118.314284
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