Ndufs2, A Core Subunit of Mitochondrial Complex I, Is Essential for Acute Oxygen-Sensing and Hypoxic Pulmonary Vasoconstriction

RATIONALE: Hypoxic pulmonary vasoconstriction (HPV) optimizes systemic oxygen delivery by matching ventilation to perfusion. HPV is intrinsic to pulmonary artery smooth muscle cells (PASMC). Hypoxia dilates systemic arteries, including renal arteries. Hypoxia is sensed by changes in mitochondrial-de...

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Gepubliceerd in:Circ Res
Hoofdauteurs: Dunham-Snary, Kimberly J, Wu, Danchen, Potus, François, Sykes, Edward A, Mewburn, Jeffrey D, Charles, Rebecca L, Eaton, Philip, Sultanian, Richard A, Archer, Stephen L
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2019
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6554062/
https://ncbi.nlm.nih.gov/pubmed/30922174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.118.314284
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