SUN-018 Epigenetic Loss of the PIWI/piRNA Machinery in Gonadal Tumors in Androgen Insensitivity Syndrome

Abstract: There is a high frequency of Testicular Germ Cell Tumors (TGCT) in 46,XY individuals with disorders of sexual development (46,XY DSD), which include Androgen Insensitivity Syndrome (AIS). That TGCT risk leads to pragmatic gonadectomy in these patients with several further implications. A b...

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Bibliographic Details
Published in:J Endocr Soc
Main Authors: Batista, Rafael, Nishi, Mirian, Rodrigues, Andresa, Costa, Elaine Maria, Domenice, Sorahia, Mendonca, Berenice
Format: Artigo
Language:Inglês
Published: Endocrine Society 2019
Subjects:
Steroid Hormones and Receptors
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6553020/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/js.2019-SUN-018
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