SUN-350 Sterol-O-Acyl Transferase 1 Protein Expression Alone Is Not Sufficient to Predict Response to Mitotane Treatment in Adrenocortical Carcinoma

Background: Objective response rate to mitotane in advanced ACC is only ~20% and adverse drug effects are frequent and potentially serious. Markers of treatment response are not established. We have previously discovered that mitotane is an inhibitor of sterol-O-Acyl transferase 1 (SOAT1) which lead...

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Vydáno v:J Endocr Soc
Hlavní autoři: Weigand, Isabel, Altieri, Barbara, Ferreira, Amanda, Basile, Vittoria, Landwehr, Laura-Sophie, Ronchi, Cristina, Schreiner, Jochen, Megerle, Felix, Berruti, Alfredo, Canu, Letizia, Volante, Marco, Paiva, Isabel, Della Casa, Silvia, Sbiera, Silviu, Fassnacht, Martin, Fragoso, Maria, Terzolo, Massimo, Kroiss, Matthias
Médium: Artigo
Jazyk:Inglês
Vydáno: Endocrine Society 2019
Témata:
Adrenal
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6553006/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/js.2019-SUN-350
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