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Defective fatty acid oxidation in mice with muscle-specific acyl-CoA synthetase 1 deficiency increases amino acid use and impairs muscle function
Loss of long-chain acyl-CoA synthetase isoform-1 (ACSL1) in mouse skeletal muscle (Acsl1(M)(−/−)) severely reduces acyl-CoA synthetase activity and fatty acid oxidation. However, the effects of decreased fatty acid oxidation on skeletal muscle function, histology, use of alternative fuels, and mitoc...
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Udgivet i: | J Biol Chem |
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Main Authors: | , , , , , , , , , , , |
Format: | Artigo |
Sprog: | Inglês |
Udgivet: |
American Society for Biochemistry and Molecular Biology
2019
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Fag: | |
Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6552438/ https://ncbi.nlm.nih.gov/pubmed/30975900 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.006790 |
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