Defective fatty acid oxidation in mice with muscle-specific acyl-CoA synthetase 1 deficiency increases amino acid use and impairs muscle function

Loss of long-chain acyl-CoA synthetase isoform-1 (ACSL1) in mouse skeletal muscle (Acsl1(M)(−/−)) severely reduces acyl-CoA synthetase activity and fatty acid oxidation. However, the effects of decreased fatty acid oxidation on skeletal muscle function, histology, use of alternative fuels, and mitoc...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Autores principales: Zhao, Liyang, Pascual, Florencia, Bacudio, Lawrence, Suchanek, Amanda L., Young, Pamela A., Li, Lei O., Martin, Sarah A., Camporez, Joao-Paulo, Perry, Rachel J., Shulman, Gerald I., Klett, Eric L., Coleman, Rosalind A.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2019
Materias:
Lipids
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6552438/
https://ncbi.nlm.nih.gov/pubmed/30975900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.006790
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