SAT-406 Deletion of Musashi in Gonadotropes Leads to Increased GnRHR Protein Levels and Gonadotrope Dysfunction

Leptin is a critical mediator of metabolic regulation of the hypothalamic-pituitary gonadal (HPG) axis. We have previously shown that leptin is responsible for the optimal expression of GnRHR, a rate-limiting component of the reproductive process. Female mice lacking leptin receptors (Lepr-null) spe...

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Pubblicato in:J Endocr Soc
Autori principali: Silva Moreira, Ana Rita, Miles, Tiffany, Haney, Anessa, Hardy, Linda, Allensworth, Melody, Kharas, Michael, Lengner, Christopher, MacNicol, Melanie, MacNicol, Angus, Childs, Gwen, Odle, Angela
Natura: Artigo
Lingua:Inglês
Pubblicazione: Endocrine Society 2019
Soggetti:
Neuroendocrinology and Pituitary
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6552265/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/js.2019-SAT-406
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